Ferric citrate contains iron that binds to the phosphates you take in through food, which helps your body absorb fewer phosphates. This can lower the amount of phosphorus (a mineral) in your blood.
Ferric citrate is used to control phosphorus levels in adults with chronic kidney disease who are on dialysis.Ferric citrate is also used to treat iron deficiency anemia in adults with chronic kidney disease who are not on dialysis.
Ferric Citrate is known chemically as iron (+3),x(1,2,3-propanetricarboxylic acid,2-hydroxy-),y(H2O). It is used to treat hyperphosphatemia and iron deficiency in CKD patients on haemodialysis or peritoneal dialysis.Ferric iron binds dietary phosphate in the GI tract and precipitates as ferric phosphate. This compound is insoluble and is excreted in the stool. By binding phosphate in the GI tract and decreasing absorption, ferric citrate lowers the phosphate concentration in the serum.
In addition to the effects on serum phosphorus levels, Ferric Citrate has been shown to increase serum iron parameters, including ferritin, iron and TSAT. In dialysis patients treated with Ferric Citrate in a 52-week study in which IV iron could also be administered, mean (SD) ferritin levels rose from 593 (293) ng/mL to 895 (482) ng/mL, mean (SD) TSAT levels rose from 31% (11) to 39% (17) and mean (SD) iron levels rose from 73 (29) mcg/dL to 88 (42) mcg/dL. In contrast, in patients treated with active control, these parameters remained relatively constant.
Ferric Citrate is contraindicated in patients with iron overload syndromes.
Pregnancy Category B: There are no adequate and well-controlled studies in pregnant women. It is not known whether Ferric Citrate can cause foetal harm when administered to a pregnant woman.
The effects of Ferric Citrate on labor and delivery are unknown
Data from rat studies have shown the transfer of iron into milk by divalent metal transporter-1 (DMT-1) and ferroportin-1 (FPN-1). Hence, there is a possibility of infant exposure when Ferric Citrate is administered to a nursing woman.
The safety and efficacy of Ferric Citrate have not been established in paediatric patients.
Clinical studies of Ferric Citrate included 106 subjects aged 65 years and older (33 subjects aged 75 years and older). Overall, the clinical study experience has not identified any obvious differences in responses between the elderly and younger patients in the tolerability or efficacy of Ferric Citrate.
|Ferric Citrate||1 gm|
|Eq.to ferric icon||210 mg|
|Colour||Red Oxide Of Iron|
As directed by physician
Keep in cool, dry & dark place
Ferric citrate is used to lower high blood phosphate levels in people who are on dialysis due to severe kidney disease. Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced. Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and may decrease the risk of heart disease and strokes that can result from high phosphate levels. This medication works by binding to phosphate in the foods you eat. The phosphate then passes out of your body in your stool.
Ferric citrate is a form of iron. This medication is also used to treat low blood levels of iron (anemia) in people with long-term kidney disease who are not on dialysis. Iron is an important mineral that your body needs to produce red blood cells and keep you in good health.